The Game was originally signed as an artist on Aftermath Entertainment, but Interscope Records CEO Jimmy Iovine and Dr. Dre decided to have The Game also work with 50 Cent and G-Unit. The arrangement was to help build a growing buzz around The Game which would also fuel interest in G-Unit. Since then he made numerous cameo appearances in music videos by 50 Cent, Lloyd Banks, Young Buck, and Fabolous. Even at this early stage in his career, he was embroiled in rap feuds associated with G-Unit, including those with Joe Budden, Ja Rule, and Memphis Bleek. His first appearance on a single was on Jim Jones' "Certified Gangstas", before his own single "Westside Story" was released in 2004.

The original title of the album was Nigga Wit' An Attitude Volume 1 (as can be seen in the lyrics to "Dreams"), but an injunction filed at the request of Eazy-E's widow prevented him from using N.W.A.'s name in the album title. Dr. Dre and 50 Cent were executive producers on The Game's major label debut album, The Documentary, which spawned the hit singles "How We Do" and "Hate It or Love It" (the latter receiving two Grammy nominations).[20] The album debuted at number one on the Billboard music charts and was the tenth best selling album of 2005 in the United States.[21] It also debuted at number seven in the United Kingdom and sold over five million copies worldwide.[22]

Due to his disputes with 50 Cent, The Game left Aftermath Entertainment and signed with Geffen Records in order to terminate his contractual obligations with G-Unit in the summer of 2006. The rapper's second album Doctor's Advocate was released on November 14, 2006. This album was set out by The Game to prove that he is able to make good music and be a successful artist without the help of Dr. Dre or 50 Cent. He is also working on getting his own label, The Black Wall Street Records, signed to a distribution label. While The Game originally claimed Dr. Dre would still do production work on the album in the November issue of XXL magazine,[23] he admitted in September (after the XXL interview was conducted) during an interview on radio station Power 105 that Dr. Dre would not be producing any tracks on the album[24] (although four previously unreleased tracks produced by Dr. Dre were released on the internet, but no reason was given as to why they were not included on the album). The album debuted at number one in the U.S., selling over 358,000 copies its first week.[25]

In May 2007, The Game said while filming Beef IV, that his tentitive third album would be his last.

Pull the rag off the six-fo',
Hit the switch, show niggas how the shit go,
The Game is back, the Aftermath chain is gone,
The D's is chrome, the frame is black.
(So watch it lift up)
Till the motherfucker bounce and break,
And knock both of the screws out the licence plate.
Let the games begin,
These other rap niggas so far behind me, go taste my rims,
Shit, let the chronic burn as the datens spin.
It ain't been this much drama since I first heard Eminem,
In the club, poppin' X pills like M & Ms,
Call it Dre day, we celebratin', bitch bring a friend.
Bottles on me, tell the waiter to order another round,
And put that cheap-ass hypnotic down.
(Put your 'cris up!)
If you feel the same way,
Who got 'em hittin' switches NY to LA

[Hook]
(Got the whole world in the club)
Hop in the low-rider, long as you got bitches in the back,
(I turn it into a strip-club)
Call it a lap-dance, when the six-fo' bounce that ass,
(Get the whole world in the club)
Tell the DJ to bang my shit, the west-coast in this bitch
(Pop bottles and twist up)
Roll up chronic and hash,
In a blunt, call it Aftermath

[Verse 2]
Somebody tell me where the drinks at,
Where the bitches at,
You fucking on the first night, meet me in the back.
I got a pound of chronic, and a gang of freaks,
Move bitch! Who the fuck you think they came to see?
The protégé of the D R E,
You take a picture with him, and you gotta fuck me,
And you gotta fuck Busta, can't touch Eve,
Got something in my waist that you can't touch either,
That's - my gangsta bitch, and like Crips and Bloods,
I'm in the club on some gangsta shit.
(So nigga twist up)
Light another dub,
Bitches get scared when niggas start fighting in the club.
Ain't nothing but a g-thing, baby it's a g-thing,
Bounce like you got hydraulics in your g-string,
I fuck a different bitch seven days a week,
Hit the switch, watch it bounce like a Scott Storch beat.

[Hook]
(Got the whole world in the club)
Hop in the low-rider, long as you got bitches in the back,
(I turn it into a strip-club)
Call it a lap-dance, when the six-fo' bounce that ass,
(Get the whole world in the club)
Tell the DJ to bang my shit, the west-coast in this bitch
(Pop bottles and twist up)
Roll up chronic and hash,
In a blunt, call it Aftermath

[Verse 3]
Who thought I weren't coming back?
Look at me now,
Hoppin' out the same Cherry six-fo' with the motherfucking top down,
I'm The Game, nigga
Call your bitch, she ain't home, she with Game, nigga
Remember that, Dre
You passed me the torch, I lit the chronic with it, now the world is my ashtray,
Ridin' three-wheel motion 'till the ass scrapes,
Turn sunset into a motherfucking drag-race.
Now watch it bounce,
Hit the switch, let it bounce till the police shut the shit down.
{When you hit the club)
Tell 'em you came with me,
(We gonna twist up)
In the V.I.P.
It's a new day, and if you ever knew Dre,
Motherfucker, you would say I was the new Dre.
Same Impala, different spokes
Same chronic, just a different smoke.

[Hook]
(Got the whole world in the club)
Hop in the low-rider, long as you got bitches in the back,
(I turn it into a strip-club)
Call it a lap-dance, when the six-fo' bounce that ass,
(Get the whole world in the club)
Tell the DJ to bang my shit, the west-coast in this bitch
(Pop bottles and twist up)
Roll up chronic and hash,
In a blunt, call it Aftermath

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